Joel and Tess spend a lot less time trying to recover their stolen merchandise from rival criminals.

Adaptational Backstory Change: Tommy is now a military veteran, as a bumper sticker on his truck indicates that he served in the First Gulf War, which was later confirmed by Joel in the second episode.

While the first part is true, effective antifungal medications exist, and in fact existed even back in 1968 when Neuman said this.

Dr Neuman in the opening scene and Dr Pertwiti in the second episode both claim that there is no vaccine or treatment for fungal infections.

In 'Please Hold to My Hand', the show does nod to Gasoline Lasts Forever by having Joel say that the gas he's siphoning out of abandoned cars will only give them enough power for a few miles in reality, the gasoline would be completely useless after a few months, let alone two decades.The American countryside outside of the Boston QZ and various ruined cities is much less wild and overgrown than it realistically would be after twenty years of little to no human interference the roads are still in fairly good condition and there are fences still standing.The Last of Us (2023) contains examples of: Troy Baker and Ashley Johnson, the original game's Joel and Ellie, also star as David's underling James and Ellie's mother Anna, respectively.

Rounding out the cast is Gabriel Luna as Joel's brother Tommy, Anna Torv as Tess, Merle Dandridge reprising her role from the original game as Marlene, Scott Shepherd as David, Nick Offerman as Bill and Murray Bartlett as Frank. He finds himself an unlikely second chance when he takes on a mission to escort a young girl named Ellie ( Bella Ramsey) on a dangerous journey across what once was the United States of America. Set twenty years after an outbreak of a strain of Cordyceps fungus infecting humans brought civilization to its knees, the series stars Pedro Pascal as Joel Miller, a man broken by the loss of his daughter (Nico Parker). On January 27, 2023, the network confirmed that the show would be renewed for a second season, which will partially adapt The Last of Us Part II, with Druckmann and Mazin planning to spread that game's storyline out over multiple seasons. The series premiered on HBO beginning on January 15, 2023. It was developed for television by Craig Mazin ( Chernobyl) and Neil Druckmann (writer and director of the original game). The Last of Us is a post-apocalyptic drama series based upon the PlayStation video game of the same name created by Naughty Dog.

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